Create a ListBoxItem, set font, content, add the ListBoxItem to the ListBox
xmlns="http://schemas.microsoft.com/winfx/2006/xaml/presentation" xmlns:x="http://schemas.microsoft.com/winfx/2006/xaml" Title="WPF" Height="300" Width="300"> List Item 1 List Item 2 List Item 3
//File:Window.xaml.vb Imports System.Windows Imports System.Windows.Controls Imports System.Windows.Media Namespace WpfApplication1 Public Partial Class Window1 Inherits Window Public Sub New() InitializeComponent() End Sub Private Sub btnAddListItem_Click(sender As Object, e As RoutedEventArgs) If textBox.Text.Length = 0 Then MessageBox.Show("Enter text to add to the list.", Title) Else Dim item As New ListBoxItem() item.Content = textBox.Text item.IsSelected = True item.HorizontalAlignment = HorizontalAlignment.Center item.FontWeight = FontWeights.Bold item.FontFamily = New FontFamily("Tahoma") listBox1.Items.Add(item) textBox.Clear() textBox.Focus() End If End Sub Private Sub btnDeleteListItem_Click(sender As Object, e As RoutedEventArgs) If listBox1.SelectedItems.Count = 0 Then MessageBox.Show("Select list items to delete.", Title) Else While listBox1.SelectedItems.Count > 0 listBox1.Items.Remove(listBox1.SelectedItems(0)) End While End If End Sub Private Sub btnSelectAll_Click(sender As Object, e As RoutedEventArgs) listBox1.SelectAll() End Sub End Class End Namespace